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  Zoloft is prescribed for major depressive disorder—a persistently low mood that interferes with everyday living. Symptoms may include loss of interest in your usual activities, disturbed sleep, change in appetite, constant fidgeting or lethargic movement, fatigue, feelings of worthlessness or guilt, difficulty thinking or concentrating. 
  This medication can also be used for the type of depression called premenstrual dysphoric disorder. In addition, Zoloft is used in the treatment of obsessive-compulsive disorder--symptoms of which include unwanted thoughts that won't go away. Zoloft is a member of the family of drugs called "selective serotonin re-uptake inhibitors." Serotonin is one of the chemical messengers believed to govern moods.
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